Market Opportunity

Acne is a large and attractive market given:

• Approximately 5 million U.S. patients with significant acne seek physician treatment, representing a target market exceeding $1 billion.

• Over $3 billion is spent annually on prescription acne therapy.

• Efficacy of current treatments is decreasing as antibiotic resistance now exceeds 50%.

• The patient population is highly motivated with demonstrated willingness to self-pay for uninsured treatments.